Semaglutide (Ozempic, Wegovy) Reduces Knee Osteoarthritis Pain, Study Finds

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Ozempic and Wegovy Show Promise for Knee Osteoarthritis Pain Relief

A recent clinical trial found that semaglutide, the active ingredient in the diabetes and weight loss drugs Ozempic and Wegovy, significantly reduced pain in patients with knee osteoarthritis and obesity.

The trial, funded by Novo Nordisk, included 407 participants, with about 82% of them being women. Participants were given either semaglutide or a placebo for 68 weeks. Pain was measured using the WOMAC (Western Ontario and McMaster Universities Arthritis Index), which evaluates pain, difficulty, and physical function in daily activities like walking or sitting.

At the start, participants had an average WOMAC pain score of 70.9. After 68 weeks, those taking semaglutide reported an average pain score of 29.2, while the placebo group reported 43.4.

In addition to pain relief, participants taking semaglutide lost an average of 13.7% of their body weight, compared to just 3.2% in the placebo group.

The study concluded that semaglutide treatment led to significant improvements in both body weight and knee pain in patients with obesity and moderate-to-severe osteoarthritis.

Knee osteoarthritis risk is notably higher in overweight and obese individuals. According to the Johns Hopkins Arthritis Center, obese women are nearly four times more likely to develop knee osteoarthritis, while obese men face a risk five times higher than non-obese individuals.